2J0D

Crystal structure of human P450 3A4 in complex with erythromycin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYTOCHROME P450 3A4	polymer	485	55481.5	2	UniProt (P08684) Pfam (PF00067)	HOMO SAPIENS (HUMAN)	QUININE 3-MONOOXYGENASE, CYPIIIA4, NIFEDIPINE OXIDASE, TAUROCHENODEOXYCHOLATE 6-ALPHA-HYDROXYLASE, NF-25, P450-PCN1
2	C, E (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D (A)	ERYTHROMYCIN A	non-polymer		733.9	1	Chemie (ERY) PubChem (16219331) PubChem (16757675) PubChem (22489166) PubChem (22836457) PubChem (22836628) PubChem (23229191) PubChem (24797108) PubChem (12560) PubChem (16219337) PubChem (16401342) PubChem (16759276) PubChem (18397931) PubChem (44451949) PubChem (18528813) PubChem (21550772) PubChem (22836626) PubChem (45107170) PubChem (45107190) PubChem (45107269) PubChem (45107273) PubChem (49867933) PubChem (51066560) PubChem (53384904) PubChem (53384913) PubChem (57358551) PubChem (44317775) PubChem (57587180) PubChem (44547821) PubChem (44563509) PubChem (45107581) PubChem (59974395) PubChem (60044171) PubChem (60086513) PubChem (66577477) PubChem (71024089) PubChem (50987679) PubChem (53393685) PubChem (54359201) PubChem (57357418) PubChem (57893297) PubChem (58594795) PubChem (58593559) PubChem (59022390) PubChem (59062422) PubChem (59064284) PubChem (59093569) PubChem (59284311) PubChem (59511080) PubChem (59897430) PubChem (59903654) PubChem (60009793) PubChem (60024420) PubChem (66639443) PubChem (66899541) PubChem (177390461) PubChem (177679009) PubChem (89970519) PubChem (3255) PubChem (8233) PubChem (9361) PubChem (90472408) PubChem (154401) PubChem (70897564) PubChem (71306958) PubChem (73265320) PubChem (73456721) PubChem (73946784) PubChem (456593) PubChem (467795) PubChem (489009) PubChem (86820632) PubChem (90473776) PubChem (90746906) PubChem (91434318) PubChem (91558259) PubChem (97293608) PubChem (99719271) PubChem (110189186) PubChem (6540620) PubChem (6602506) PubChem (6604221) PubChem (124226124) PubChem (124518166) PubChem (124604978) PubChem (124605145) PubChem (124605175) PubChem (124723146) PubChem (124798369) PubChem (124762348) PubChem (124822557) PubChem (9833120) PubChem (10032882) PubChem (6364614) PubChem (129009922) PubChem (129125718) PubChem (129445574) PubChem (129445576) PubChem (129666958) PubChem (10897911) PubChem (132274086) PubChem (97293607) PubChem (6604684) PubChem (6713919) PubChem (133126690) PubChem (133126790) PubChem (133550114) PubChem (133688268) PubChem (134081643) PubChem (134081274) PubChem (99719272) PubChem (134693955) PubChem (118725304) PubChem (11970254) PubChem (10034134) PubChem (12358519) PubChem (12358515) PubChem (12358508) PubChem (137705094) PubChem (124226125) PubChem (139247122) PubChem (124523502) PubChem (141945645) PubChem (124604979) PubChem (124605144) PubChem (124605146) PubChem (124716782) PubChem (124716783) PubChem (124723147) PubChem (124762349) PubChem (12358509) PubChem (12358517) PubChem (12966969) PubChem (15986867) PubChem (124822555) PubChem (124822558) PubChem (124870987) PubChem (146158524) PubChem (157254288) PubChem (163003493) PubChem (163003495) PubChem (165844830) PubChem (169440260) PubChem (126969058) PubChem (129010384) PubChem (172897573) PubChem (129119817) PubChem (129445575) PubChem (129627840) PubChem (129628729) PubChem (131665174) PubChem (133562871) PubChem (133602826) PubChem (134081264) PubChem (134693174) PubChem (135026875) PubChem (138113460) PubChem (138403276) PubChem (140886742) PubChem (141646830) PubChem (145774355) PubChem (155899868) PubChem (155900413) PubChem (161123720) PubChem (163003494) PubChem (163003496) PubChem (166604455) PubChem (166639762) PubChem (169289157) PubChem (171114703) PubChem (172897571) PubChem (16212992) PubChem (16213052)
4	F, G (A, B)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B: 23 - 24 (PDB: 2J0D)
A, B: 504 - 507 (PDB: 2J0D)
A, B: 25 - 503 (UniProt: P08684)

PDB	External Database	Details
Val 392	Trp 391	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	110963.0
Non-Polymers*	Number of molecules	3
	Total formula weight	1966.9
All*	Total formula weight	112929.9

*Water molecules are not included.