3NXU
Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytochrome P450 3A4 | polymer | 485 | 55481.5 | 2 | UniProt (P08684) Pfam (PF00067) | Homo sapiens (human) | Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Cytochrome P450 3A3, CYPIIIA3, Cytochrome P450 HLp, Taurochenodeoxycholate 6-alpha-hydroxylase, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Albendazole monooxygenase, Albendazole sulfoxidase |
| 2 | C, D, E, F, I... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
| 3 | G, K (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 4 | H, L (A, B) | RITONAVIR | non-polymer | 720.9 | 2 | BIRD (PRD_001001) Chemie (RIT) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | SEE REMARK 999 |
| Ala 24 | - | SEE REMARK 999 |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 110963.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3143.7 | |
| All* | Total formula weight | 114106.6 |
