3NXU
Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cytochrome P450 3A4 | polymer | 485 | 55481.5 | 2 | UniProt (P08684) Pfam (PF00067) In PDB | Homo sapiens (human) | Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Cytochrome P450 3A3, CYPIIIA3, Cytochrome P450 HLp, Taurochenodeoxycholate 6-alpha-hydroxylase, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Albendazole monooxygenase, Albendazole sulfoxidase |
2 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
3 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
4 | A, B | RITONAVIR | non-polymer | 720.9 | 2 | BIRD (PRD_001001) Chemie (RIT) | |||
5 | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 503 (UniProt: P08684)
PDB | External Database | Details |
---|---|---|
Met 23 | - | SEE REMARK 999 |
Ala 24 | - | SEE REMARK 999 |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 110963.0 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3143.7 | |
All* | Total formula weight | 114106.6 |