3NU5

Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir

3NU5 の概要

• エントリーDOI: 10.2210/pdb3nu5/pdb
• 関連するPDBエントリー: 2IEN 3NU3 3NU4 3NU6 3NU9 3NUJ 3NUO
• 分子名称: protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: enzyme inhibition, aspartic protease, hiv/aids, conformational change, amprenavir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22394.15

構造登録者

Wang, Y.-F.,Shen, C.H.,Weber, I.T. (登録日: 2010-07-06, 公開日: 2010-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Shen, C.H.,Wang, Y.F.,Kovalevsky, A.Y.,Harrison, R.W.,Weber, I.T.; Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.; Febs J., 277:3699-3714, 2010; PubMed: 20695887; DOI: 10.1111/j.1742-4658.2010.07771.x

実験手法

X-RAY DIFFRACTION (1.29 Å)