3NUO

Crystal Structure of HIV-1 Protease Mutant L90M with Antiviral Drug Amprenavir

Summary for 3NUO

Entry DOI	10.2210/pdb3nuo/pdb
Related	2IEN 3NU3 3NU4 3NU5 3NU6 3NU9 3NUJ
Descriptor	Protease, IODIDE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total)
Functional Keywords	enzyme inhibition, aspartic protease, hiv/aids, conformational change, amprenavir, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
Total number of polymer chains	2
Total formula weight	24434.23
Authors	Shen, C.H.,Weber, I.T. (deposition date: 2010-07-07, release date: 2010-08-25, Last modification date: 2024-02-21)
Primary citation	Shen, C.H.,Wang, Y.F.,Kovalevsky, A.Y.,Harrison, R.W.,Weber, I.T. Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters. Febs J., 277:3699-3714, 2010 Cited by PubMed: 20695887 DOI: 10.1111/j.1742-4658.2010.07771.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation