Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 501 |
| Chain | Residue |
| A | ASP60 |
| A | HOH1013 |
| A | HOH1022 |
| A | HOH1066 |
| A | HOH1073 |
| A | HOH1085 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 511 |
| Chain | Residue |
| B | ARG141 |
| A | THR74 |
| A | ASN88 |
| A | HOH1105 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 517 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 802 |
| Chain | Residue |
| A | GLN18 |
| A | MET36 |
| A | SER37 |
| A | HOH1033 |
| B | THR112 |
| B | GLU165 |
| B | ACT801 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE 478 B 401 |
| Chain | Residue |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | VAL50 |
| A | VAL82 |
| A | ILE84 |
| A | HOH1155 |
| B | LEU123 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | VAL132 |
| B | GLY148 |
| B | GLY149 |
| B | VAL150 |
| B | PRO181 |
| B | VAL182 |
| B | ILE184 |
| B | HOH1001 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 502 |
| Chain | Residue |
| B | ASP160 |
| B | HOH1023 |
| B | HOH1113 |
| B | HOH1177 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 503 |
| Chain | Residue |
| B | HOH1157 |
| B | HOH1158 |
| B | HOH1159 |
| B | HOH1160 |
| B | HOH1161 |
| B | HOH1162 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 512 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 513 |
| Chain | Residue |
| B | THR174 |
| B | ASN188 |
| B | HOH1025 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 514 |
| Chain | Residue |
| B | THR112 |
| B | HOH1174 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 515 |
| Chain | Residue |
| B | LYS120 |
| B | GLU121 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 516 |
| Chain | Residue |
| B | GLN118 |
| B | MET136 |
| B | SER137 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 801 |
| Chain | Residue |
| A | ACT802 |
| B | THR112 |
| B | ILE113 |
| B | LYS114 |
| B | GLU165 |
| B | ILE166 |
| B | ALA167 |
| B | GLY168 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12924029","evidenceCode":"ECO:0000269"}]} |
