3NU5
Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10726.6 | 2 | UniProt (P03366) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C, H, I (A, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 3 | D, E, J, K, L... (A, B) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 4 | F, O (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | G (B) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Val 50 | Ile 550 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21453.3 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 940.9 | |
| All* | Total formula weight | 22394.2 |
