3NTB

Structure of 6-methylthio naproxen analog bound to mCOX-2.

Summary for 3NTB

Related3PGH 1PXX 1CQE 3NT1
DescriptorProstaglandin-endoperoxide synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordsprostaglandin h2 synthase, cyclooxygeanse-2, naproxen analog, oxidoreductase
Biological sourceMus musculus (mouse)
Total number of polymer chains4
Total molecular weight278960.47
Authors
Duggan, K.C.,Musee, J.,Walters, M.J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. (deposition date: 2010-07-03, release date: 2010-09-01, Last modification date: 2017-11-08)
Primary citation
Duggan, K.C.,Walters, M.J.,Musee, J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J.
Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285:34950-34959, 2010
PubMed: 20810665 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.162982
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.27 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27520.0%1.0%9.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3ntb
no rotation
Molmil generated image of 3ntb
rotated about x axis by 90°
Molmil generated image of 3ntb
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3ntb
no rotation
Molmil generated image of 3ntb
rotated about x axis by 90°
Molmil generated image of 3ntb
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3ntb.pdb1.gz [390.04 KB])
Coordinate files for Biological unit (3ntb.pdb2.gz [387.99 KB])