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1PXX

CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

Summary for 1PXX
Entry DOI10.2210/pdb1pxx/pdb
Related1CVU 6COX
Related PRD IDPRD_900017
DescriptorProstaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordscox-2, cyclooxygenase, prostaglandin, diclofenac, endoperoxide, oxidoreductase
Biological sourceMus musculus (house mouse)
Total number of polymer chains4
Total formula weight284886.98
Authors
Kiefer, J.R.,Rowlinson, S.W.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Marnett, L.J.,Kurumbail, R.G. (deposition date: 2003-07-07, release date: 2003-09-09, Last modification date: 2020-07-29)
Primary citationRowlinson, S.W.,Kiefer, J.R.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Kurumbail, R.G.,Marnett, L.J.
A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385.
J.Biol.Chem., 278:45763-45769, 2003
Cited by
PubMed: 12925531
DOI: 10.1074/jbc.M305481200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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