3NT1

High resolution structure of naproxen:COX-2 complex.

Summary for 3NT1

Entry DOI	10.2210/pdb3nt1/pdb
Related	1CQE 1PXX 3NTB 3PGH
Descriptor	Prostaglandin-endoperoxide synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	prostaglandin h2 synthase, cyclooxygenase-2, naproxen, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	139332.93
Authors	Duggan, K.C.,Musee, J.,Walters, M.J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. (deposition date: 2010-07-02, release date: 2010-09-01, Last modification date: 2023-12-27)
Primary citation	Duggan, K.C.,Walters, M.J.,Musee, J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J.Biol.Chem., 285:34950-34959, 2010 Cited by PubMed: 20810665 DOI: 10.1074/jbc.M110.162982 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation