3NBN

Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA

3NBN の概要

• エントリーDOI: 10.2210/pdb3nbn/pdb
• 分子名称: Recombining binding protein suppressor of hairless, Neurogenic locus notch homolog protein 1, Mastermind-like protein 1, ... (5 entities in total)
• 機能のキーワード: promoter regions, notch1, csl, rbpj, mastermind, transcription factors, transcription, transcriptional activation, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q06330; Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531; Nucleus speckle : Q92585
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 192047.56

構造登録者

Arnett, K.L.,Blacklow, S.C. (登録日: 2010-06-03, 公開日: 2010-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Arnett, K.L.,Hass, M.,McArthur, D.G.,Ilagan, M.X.,Aster, J.C.,Kopan, R.,Blacklow, S.C.; Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.; Nat.Struct.Mol.Biol., 17:1312-1317, 2010; PubMed: 20972443; DOI: 10.1038/nsmb.1938

実験手法

X-RAY DIFFRACTION (3.45 Å)