3N57
Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)
Summary for 3N57
Entry DOI | 10.2210/pdb3n57/pdb |
Related | 1T34 1YK0 2G47 2WBY 3CWW 3H44 3N56 |
Descriptor | Insulin-degrading enzyme, Atrial natriuretic factor, ZINC ION, ... (4 entities in total) |
Functional Keywords | insulysin, insulinase, a-beta degrading enzyme, cryptidase, hydrolase, hormone, disease mutation, diabetes mellitus, insulin, cardiac, secreted, protease, disulfide bond, metalloprotease, human insulin-degradng enzyme, metal-binding, natriuretic peptide, natriuretic factor, cardiovascular regulation, hydrolase-hormone complex, hydrolase/hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 Secreted: P01160 |
Total number of polymer chains | 4 |
Total formula weight | 235426.98 |
Authors | Funke, T.,Guo, Q.,Tang, W.-J. (deposition date: 2010-05-24, release date: 2010-11-17, Last modification date: 2024-02-21) |
Primary citation | Ralat, L.A.,Funke, T.,Ren, M.,Guo, Q.,Dickey, D.M.,Potter, L.R.,Tang, W.-J. Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP) To be Published, |
Experimental method | X-RAY DIFFRACTION (3.03 Å) |
Structure validation
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