3MZF

Structure of penicillin-binding protein 5 from E. coli: imipenem acyl-enzyme complex

Summary for 3MZF

Entry DOI	10.2210/pdb3mzf/pdb
Related	1NZO 1Z6F 3BEB 3BEC 3MZD 3MZE
Descriptor	D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	beta-lactam antibiotic, penicillin-binding protein, dd-carboxypeptidase, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	40234.57
Authors	Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C. (deposition date: 2010-05-12, release date: 2011-03-16, Last modification date: 2023-09-06)
Primary citation	Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C. Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity Biochemistry, 49:8094-8104, 2010 Cited by PubMed: 20726582 DOI: 10.1021/bi100879m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation