3MZE

Structure of penicillin-binding protein 5 from E.coli: cefoxitin acyl-enzyme complex

Summary for 3MZE

Entry DOI	10.2210/pdb3mze/pdb
Related	1NZO 1Z6F 3BEB 3BEC 3MZD 3MZF
Descriptor	D-alanyl-D-alanine carboxypeptidase dacA, (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	beta-lactam antibiotic, penicillin-binding protein, dd-carboxypeptidase, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	40638.96
Authors	Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C. (deposition date: 2010-05-12, release date: 2011-03-16, Last modification date: 2023-09-06)
Primary citation	Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C. Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity Biochemistry, 49:8094-8104, 2010 Cited by PubMed: 20726582 DOI: 10.1021/bi100879m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation