3BEC

Crystal structure of E. coli penicillin-binding protein 5 in complex with a peptide-mimetic cephalosporin

Summary for 3BEC

Entry DOI	10.2210/pdb3bec/pdb
Related	3BEB
Descriptor	Penicillin-binding protein 5, GLYCEROL, (2R)-2-[(R)-{[(6S)-6-amino-6-carboxyhexanoyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	peptidoglycan synthesis, penicillin-binding protein, dd-carboxypeptidase, hydrolase, designed cephalosporin, cell shape, cell wall biogenesis/degradation, inner membrane, membrane, protease
Biological source	Escherichia coli
Cellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side: P0AEB2
Total number of polymer chains	1
Total formula weight	40598.92
Authors	Powell, A.J.,Davies, C. (deposition date: 2007-11-16, release date: 2008-08-26, Last modification date: 2023-08-30)
Primary citation	Sauvage, E.,Powell, A.J.,Heilemann, J.,Josephine, H.R.,Charlier, P.,Davies, C.,Pratt, R.F. Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle J.Mol.Biol., 381:383-393, 2008 Cited by PubMed: 18602645 DOI: 10.1016/j.jmb.2008.06.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation