3MZF

Structure of penicillin-binding protein 5 from E. coli: imipenem acyl-enzyme complex

3MZF の概要

• エントリーDOI: 10.2210/pdb3mzf/pdb
• 関連するPDBエントリー: 1NZO 1Z6F 3BEB 3BEC 3MZD 3MZE
• 分子名称: D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: beta-lactam antibiotic, penicillin-binding protein, dd-carboxypeptidase, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40234.57

構造登録者

Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C. (登録日: 2010-05-12, 公開日: 2011-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Nicola, G.,Tomberg, J.,Pratt, R.F.,Nicholas, R.A.,Davies, C.; Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity; Biochemistry, 49:8094-8104, 2010; PubMed: 20726582; DOI: 10.1021/bi100879m

実験手法

X-RAY DIFFRACTION (1.5 Å)