Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

Summary for 3MY0

DescriptorSerine/threonine-protein kinase receptor R3, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline (3 entities in total)
Functional Keywordsprotein kinase, serine/threonine-protein kinase receptor, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P37023
Total number of polymer chains24
Total molecular weight845164.82
Primary citation
Kerr, G.,Sheldon, H.,Chaikuad, A.,Alfano, I.,von Delft, F.,Bullock, A.N.,Harris, A.L.
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Angiogenesis, 18:209-217, 2015
PubMed: 25557927 (PDB entries with the same primary citation)
DOI: 10.1007/s10456-014-9457-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2329 0.9% 4.1% 9.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-14