3MY0
Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189
Summary for 3MY0
Entry DOI | 10.2210/pdb3my0/pdb |
Descriptor | Serine/threonine-protein kinase receptor R3, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline (3 entities in total) |
Functional Keywords | protein kinase, serine/threonine-protein kinase receptor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P37023 |
Total number of polymer chains | 24 |
Total formula weight | 845164.82 |
Authors | Chaikuad, A.,Alfano, I.,Cooper, C.,Mahajan, P.,Daga, N.,Sanvitale, C.,Fedorov, O.,Petrie, K.,Savitsky, P.,Gileadi, O.,Sethi, R.,Krojer, T.,Muniz, J.R.C.,Pike, A.C.W.,Vollmar, M.,Carpenter, C.P.,Ugochukwu, E.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-05-08, release date: 2010-07-21, Last modification date: 2023-11-01) |
Primary citation | Kerr, G.,Sheldon, H.,Chaikuad, A.,Alfano, I.,von Delft, F.,Bullock, A.N.,Harris, A.L. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis, 18:209-217, 2015 Cited by PubMed: 25557927DOI: 10.1007/s10456-014-9457-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report