3MY0
Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Serine/threonine-protein kinase receptor R3 | polymer | 305 | 34808.7 | 24 | UniProt (P37023) Pfam (PF07714) | Homo sapiens (human) | SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I |
| 2 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | non-polymer | 406.5 | 24 | Chemie (LDN) | |||
| 3 | AB, BB, CB, DB, EB... (E, F, G, H, I...) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X: 195 - 497 (UniProt: P37023)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 835409.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 9755.6 | |
| All* | Total formula weight | 845164.8 |
