Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MY0

Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0004672	molecular_function	protein kinase activity
B	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
B	0016020	cellular_component	membrane
C	0004672	molecular_function	protein kinase activity
C	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
C	0016020	cellular_component	membrane
D	0004672	molecular_function	protein kinase activity
D	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
D	0016020	cellular_component	membrane
E	0004672	molecular_function	protein kinase activity
E	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
E	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
E	0016020	cellular_component	membrane
F	0004672	molecular_function	protein kinase activity
F	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
F	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
F	0016020	cellular_component	membrane
G	0004672	molecular_function	protein kinase activity
G	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
G	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
G	0016020	cellular_component	membrane
H	0004672	molecular_function	protein kinase activity
H	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
H	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
H	0016020	cellular_component	membrane
I	0004672	molecular_function	protein kinase activity
I	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
I	0005524	molecular_function	ATP binding
I	0006468	biological_process	protein phosphorylation
I	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
I	0016020	cellular_component	membrane
J	0004672	molecular_function	protein kinase activity
J	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
J	0005524	molecular_function	ATP binding
J	0006468	biological_process	protein phosphorylation
J	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
J	0016020	cellular_component	membrane
K	0004672	molecular_function	protein kinase activity
K	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
K	0005524	molecular_function	ATP binding
K	0006468	biological_process	protein phosphorylation
K	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
K	0016020	cellular_component	membrane
L	0004672	molecular_function	protein kinase activity
L	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
L	0005524	molecular_function	ATP binding
L	0006468	biological_process	protein phosphorylation
L	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
L	0016020	cellular_component	membrane
M	0004672	molecular_function	protein kinase activity
M	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
M	0005524	molecular_function	ATP binding
M	0006468	biological_process	protein phosphorylation
M	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
M	0016020	cellular_component	membrane
N	0004672	molecular_function	protein kinase activity
N	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
N	0005524	molecular_function	ATP binding
N	0006468	biological_process	protein phosphorylation
N	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
N	0016020	cellular_component	membrane
O	0004672	molecular_function	protein kinase activity
O	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
O	0005524	molecular_function	ATP binding
O	0006468	biological_process	protein phosphorylation
O	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
O	0016020	cellular_component	membrane
P	0004672	molecular_function	protein kinase activity
P	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
P	0005524	molecular_function	ATP binding
P	0006468	biological_process	protein phosphorylation
P	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
P	0016020	cellular_component	membrane
Q	0004672	molecular_function	protein kinase activity
Q	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
Q	0005524	molecular_function	ATP binding
Q	0006468	biological_process	protein phosphorylation
Q	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
Q	0016020	cellular_component	membrane
R	0004672	molecular_function	protein kinase activity
R	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
R	0005524	molecular_function	ATP binding
R	0006468	biological_process	protein phosphorylation
R	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
R	0016020	cellular_component	membrane
S	0004672	molecular_function	protein kinase activity
S	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
S	0005524	molecular_function	ATP binding
S	0006468	biological_process	protein phosphorylation
S	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
S	0016020	cellular_component	membrane
T	0004672	molecular_function	protein kinase activity
T	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
T	0005524	molecular_function	ATP binding
T	0006468	biological_process	protein phosphorylation
T	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
T	0016020	cellular_component	membrane
U	0004672	molecular_function	protein kinase activity
U	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
U	0005524	molecular_function	ATP binding
U	0006468	biological_process	protein phosphorylation
U	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
U	0016020	cellular_component	membrane
V	0004672	molecular_function	protein kinase activity
V	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
V	0005524	molecular_function	ATP binding
V	0006468	biological_process	protein phosphorylation
V	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
V	0016020	cellular_component	membrane
W	0004672	molecular_function	protein kinase activity
W	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
W	0005524	molecular_function	ATP binding
W	0006468	biological_process	protein phosphorylation
W	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
W	0016020	cellular_component	membrane
X	0004672	molecular_function	protein kinase activity
X	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation
X	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
X	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN A 600

Chain	Residue
A	VAL216
A	ARG334
A	ASN335
A	LEU337
F	ARG291
A	ALA227
A	LYS229
A	THR277
A	HIS278
A	TYR279
A	GLU281
A	GLY283
A	ASP287

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN B 600

Chain	Residue
B	LEU257
B	THR277
B	HIS278
B	TYR279
B	HIS280
B	GLU281
B	HIS282
B	GLY283
B	ASP287
B	ARG291
B	ARG334
B	ASN335
B	LEU337
B	ALA347
B	ASP348

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LDN C 600

Chain	Residue
C	VAL208
C	VAL216
C	ALA227
C	LEU257
C	THR277
C	HIS278
C	TYR279
C	HIS280
C	GLU281
C	ARG334
C	ASN335
C	LEU337

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN D 600

Chain	Residue
D	VAL208
D	VAL216
D	ALA227
D	LEU257
D	THR277
D	HIS278
D	TYR279
D	HIS280
D	GLU281
D	GLY283
D	ASP287
D	ARG334
D	LEU337

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN E 600

Chain	Residue
E	VAL216
E	ALA227
E	LEU257
E	THR277
E	HIS278
E	HIS280
E	GLU281
E	GLY283
E	ASP287
E	ARG334
E	ASN335
E	LEU337
E	ALA347
H	ARG291

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN F 600

Chain	Residue
A	ARG291
F	VAL216
F	ALA227
F	LEU257
F	THR277
F	HIS278
F	HIS280
F	GLU281
F	GLY283
F	ASP287
F	ARG334
F	ASN335
F	LEU337
F	ALA347

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN G 600

Chain	Residue
G	VAL208
G	ALA227
G	LEU257
G	THR277
G	HIS278
G	TYR279
G	HIS280
G	GLU281
G	GLY283
G	ARG334
G	ASN335
G	LEU337
G	ALA347
J	ARG291

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN H 600

Chain	Residue
H	HIS278
H	TYR279
H	HIS280
H	GLU281
H	GLY283
H	ASP287
H	ARG334
H	ASN335
H	LEU337
H	ALA347
E	ARG291
H	ALA227
H	LEU257
H	THR277

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN I 600

Chain	Residue
I	VAL208
I	VAL216
I	ALA227
I	LEU257
I	THR277
I	HIS278
I	TYR279
I	HIS280
I	GLU281
I	GLY283
I	ASP287
I	ARG334
I	ASN335
I	LEU337
I	ALA347

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN J 600

Chain	Residue
G	ARG291
J	VAL208
J	VAL216
J	ALA227
J	THR277
J	TYR279
J	HIS280
J	GLU281
J	GLY283
J	ASP287
J	ARG334
J	LEU337
J	ALA347

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LDN K 600

Chain	Residue
K	VAL208
K	ALA227
K	LEU257
K	THR277
K	HIS278
K	TYR279
K	HIS280
K	GLY283
K	ASP287
K	LEU337
K	ALA347
K	ASP348

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN L 600

Chain	Residue
L	VAL216
L	ALA227
L	LYS229
L	LEU257
L	THR277
L	HIS278
L	HIS280
L	GLU281
L	GLY283
L	ASP287
L	ARG291
L	ARG334
L	ASN335
L	LEU337
Q	ARG291

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN M 600

Chain	Residue
M	VAL208
M	VAL216
M	ALA227
M	LEU257
M	THR277
M	HIS278
M	TYR279
M	HIS280
M	GLU281
M	GLY283
M	ASP287
M	ARG291
M	LEU337

site_id	BC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN N 600

Chain	Residue
N	VAL208
N	VAL216
N	ALA227
N	LEU257
N	THR277
N	TYR279
N	HIS280
N	GLU281
N	GLY283
N	ARG291
N	ARG334
N	ASN335
N	LEU337

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LDN O 600

Chain	Residue
O	ALA227
O	LEU257
O	THR277
O	HIS278
O	HIS280
O	GLU281
O	GLY283
O	ASP287
O	ARG334
O	ASN335
O	LEU337
O	ALA347

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN P 600

Chain	Residue
P	VAL208
P	ALA227
P	LYS229
P	LEU257
P	THR277
P	HIS278
P	HIS280
P	GLU281
P	GLY283
P	ASP287
P	ARG334
P	ASN335
P	LEU337
P	ALA347
S	ARG291

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN Q 600

Chain	Residue
L	ARG291
L	GLN292
Q	VAL208
Q	VAL216
Q	ALA227
Q	LEU257
Q	THR277
Q	HIS278
Q	TYR279
Q	HIS280
Q	GLU281
Q	GLY283
Q	ASP287
Q	ASN335
Q	LEU337

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LDN R 600

Chain	Residue
R	ALA227
R	LEU257
R	THR277
R	HIS278
R	HIS280
R	GLU281
R	GLY283
R	ASP287
R	ASN335
R	LEU337
R	ALA347
U	ARG291

site_id	CC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN S 600

Chain	Residue
P	ARG291
S	VAL208
S	VAL216
S	LYS229
S	LEU257
S	THR277
S	HIS278
S	TYR279
S	HIS280
S	GLU281
S	GLY283
S	ARG334
S	ASN335
S	LEU337

site_id	CC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LDN T 600

Chain	Residue
T	VAL208
T	VAL216
T	ALA227
T	LYS229
T	THR277
T	TYR279
T	HIS280
T	GLU281
T	GLY283
T	ASP287
T	LEU337

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LDN U 600

Chain	Residue
R	ARG291
U	VAL208
U	VAL216
U	LEU257
U	THR277
U	HIS278
U	TYR279
U	HIS280
U	GLU281
U	GLY283
U	ASN335
U	LEU337

site_id	CC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LDN V 600

Chain	Residue
V	VAL216
V	ALA227
V	LEU257
V	THR277
V	HIS278
V	TYR279
V	HIS280
V	GLU281
V	GLY283
V	ASP287
V	ARG334
V	ASN335
V	LEU337
V	ALA347

site_id	CC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LDN W 600

Chain	Residue
W	VAL208
W	ALA227
W	LEU257
W	THR277
W	HIS278
W	TYR279
W	HIS280
W	GLU281
W	GLY283
W	ASP287
W	ARG291
W	ARG334
W	ASN335
W	LEU337
W	ALA347

site_id	CC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LDN X 600

Chain	Residue
X	ALA227
X	LYS229
X	HIS278
X	HIS280
X	GLU281
X	HIS282
X	GLY283
X	ASP287
X	ARG334
X	ASN335
X	LEU337
X	ALA347
X	ASP348

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGlwhges............VAVK

Chain	Residue	Details
A	VAL208-LYS229

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDFKsrNVLV

Chain	Residue	Details
A	ILE326-VAL338

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	216
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	580
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)