3MXW
Crystal structure Sonic hedgehog bound to the 5E1 fab fragment
Summary for 3MXW
Entry DOI | 10.2210/pdb3mxw/pdb |
Related | 1VHH 3M1N 3MXV |
Descriptor | Sonic hedgehog protein, 5E1 light chain, 5E1 heavy chain, ... (7 entities in total) |
Functional Keywords | antibody complex, fab fragment, metalloprotease, calcium binding, zinc hydrolase, development, morphogen, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465 |
Total number of polymer chains | 3 |
Total formula weight | 66879.98 |
Authors | Hymowitz, S.G.,Maun, H.R. (deposition date: 2010-05-07, release date: 2010-05-26, Last modification date: 2023-09-06) |
Primary citation | Maun, H.R.,Wen, X.,Lingel, A.,de Sauvage, F.J.,Lazarus, R.A.,Scales, S.J.,Hymowitz, S.G. Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J.Biol.Chem., 285:26570-26580, 2010 Cited by PubMed: 20504762DOI: 10.1074/jbc.M110.112284 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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