3MVJ

Human cyclic AMP-dependent protein kinase PKA inhibitor complex

3MVJ の概要

• エントリーDOI: 10.2210/pdb3mvj/pdb
• 関連するPDBエントリー: 3MV5 3MVH
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 136053.52

構造登録者

Pandit, J.,Vajdos, F. (登録日: 2010-05-04, 公開日: 2010-06-02, 最終更新日: 2017-11-08)

• 主引用文献: Freeman-Cook, K.D.,Autry, C.,Borzillo, G.,Gordon, D.,Barbacci-Tobin, E.,Bernardo, V.,Briere, D.,Clark, T.,Corbett, M.,Jakubczak, J.,Kakar, S.,Knauth, E.,Lippa, B.,Luzzio, M.J.,Mansour, M.,Martinelli, G.,Marx, M.,Nelson, K.,Pandit, J.,Rajamohan, F.,Robinson, S.,Subramanyam, C.,Wei, L.,Wythes, M.,Morris, J.; Design of selective, ATP-competitive inhibitors of Akt.; J.Med.Chem., 53:4615-4622, 2010; PubMed: 20481595; DOI: 10.1021/jm1003842

実験手法

X-RAY DIFFRACTION (2.49 Å)