3MVJ

Human cyclic AMP-dependent protein kinase PKA inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E	cAMP-dependent protein kinase catalytic subunit alpha	polymer	371	42979.9	3	UniProt (P17612) Pfam (PF00069) In PDB	Homo sapiens (human)	PKA C-alpha
2	I, J, K	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2226.4	3	UniProt (P61925) In PDB		PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform
3	A, E	(3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine	non-polymer		217.3	2	Chemie (XFE)
4		water	water		18.0	231	Chemie (HOH)

Sequence modifications

A, B, E: 0 - 350 (UniProt: P17612)

PDB	External Database	Details
Met -20	-	EXPRESSION TAG
Gly -19	-	EXPRESSION TAG
Ser -18	-	EXPRESSION TAG
Ser -17	-	EXPRESSION TAG
His -16	-	EXPRESSION TAG
His -15	-	EXPRESSION TAG
His -14	-	EXPRESSION TAG
His -13	-	EXPRESSION TAG
His -12	-	EXPRESSION TAG
His -11	-	EXPRESSION TAG
Ser -10	-	EXPRESSION TAG
Ser -9	-	EXPRESSION TAG
Gly -8	-	EXPRESSION TAG
Leu -7	-	EXPRESSION TAG
Val -6	-	EXPRESSION TAG
Pro -5	-	EXPRESSION TAG
Arg -4	-	EXPRESSION TAG
Gly -3	-	EXPRESSION TAG
Ser -2	-	EXPRESSION TAG
His -1	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	135619.0
Non-Polymers*	Number of molecules	2
	Total formula weight	434.5
All*	Total formula weight	136053.5

*Water molecules are not included.