3MTN
Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
Summary for 3MTN
Entry DOI | 10.2210/pdb3mtn/pdb |
Related | 3I3T |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 21, UBIQUITIN VARIANT UBV.21.4, ZINC ION, ... (6 entities in total) |
Functional Keywords | ubiquitin-specific protease activity, hydrolase, ubiquitin biology, structural genomics consortium, sgc, activator, chromatin regulator, nucleus, protease, thiol protease, transcription, transcription regulation, ubl conjugation pathway, isopeptide bond, phosphoprotein, inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q9UK80 |
Total number of polymer chains | 4 |
Total formula weight | 103043.34 |
Authors | Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Ernst, A.,Sidhu, S.,Weigelt, J.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-30, release date: 2010-06-09, Last modification date: 2023-09-06) |
Primary citation | Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S. A strategy for modulation of enzymes in the ubiquitin system. Science, 339:590-595, 2013 Cited by PubMed: 23287719DOI: 10.1126/science.1230161 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report