3MJR

Human dCK complex with Acyclic Nucleoside

3MJR の概要

• エントリーDOI: 10.2210/pdb3mjr/pdb
• 分子名称: Deoxycytidine kinase, 9-HYROXYETHOXYMETHYLGUANINE, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: acv, gcv, dck, kinase, udp, p-loop, kinase activity, nucleoside kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P27707
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132582.30

構造登録者

Hazra, S.,Lavie, A. (登録日: 2010-04-13, 公開日: 2010-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Hazra, S.,Konrad, M.,Lavie, A.; The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.; J.Med.Chem., 53:5792-5800, 2010; PubMed: 20684612; DOI: 10.1021/jm1005379

実験手法

X-RAY DIFFRACTION (2.1 Å)