3MA2

Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1)

Summary for 3MA2

Entry DOI	10.2210/pdb3ma2/pdb
Related	1BQQ
Descriptor	Matrix metalloproteinase-14, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total)
Functional Keywords	protein - protein complex, cleavage on pair of basic residues, disulfide bond, membrane, metal-binding, metalloprotease, protease, transmembrane, zymogen, erythrocyte maturation, glycoprotein, metalloenzyme inhibitor, metalloprotease inhibitor, secreted, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Membrane ; Single-pass type I membrane protein : P50281 Secreted : P01033
Total number of polymer chains	4
Total formula weight	69797.72
Authors	Grossman, M.,Tworowski, D.,Dym, O.,Lee, M.-H.,Levy, Y.,Sagi, I. (deposition date: 2010-03-23, release date: 2010-06-30, Last modification date: 2023-09-06)
Primary citation	Grossman, M.,Tworowski, D.,Dym, O.,Lee, M.H.,Levy, Y.,Murphy, G.,Sagi, I. The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function. Biochemistry, 49:6184-6192, 2010 Cited by PubMed: 20545310 DOI: 10.1021/bi902141x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation