3MA2
Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, A) | Matrix metalloproteinase-14 | polymer | 181 | 20561.7 | 2 | UniProt (P50281) Pfam (PF00413) | Homo sapiens (human) | MMP-14, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP-X1 |
| 2 | C, D (B, C) | Metalloproteinase inhibitor 1 | polymer | 125 | 14126.2 | 2 | UniProt (P01033) Pfam (PF00965) | Homo sapiens (human) | Tissue inhibitor of metalloproteinases 1, TIMP-1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor |
| 3 | E, H, I, L (D, A) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | F, G, J, K (D, A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | M, N, O, P (D, A, B, C) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
B, C: 301 - 425 (UniProt: P01033)
| PDB | External Database | Details |
|---|---|---|
| Ala 304 | Val 27 | engineered mutation |
| Val 306 | Pro 29 | engineered mutation |
| Leu 398 | Thr 121 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 69375.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 421.9 | |
| All* | Total formula weight | 69797.7 |
