3MA2

Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0008191	molecular_function	metalloendopeptidase inhibitor activity
C	0008191	molecular_function	metalloendopeptidase inhibitor activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 293

Chain	Residue
D	HOH23
D	HOH26
D	ASP176
D	ASN208
D	GLY210
D	ASP212

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 294

Chain	Residue
D	HIS249
C	CYS301
D	HIS239
D	HIS243

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 295

Chain	Residue
D	HIS186
D	ASP188
D	HIS201
D	HIS214

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 296

Chain	Residue
D	ASP193
D	GLY194
D	GLY196
D	PHE198
D	ASP216
D	GLU219

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 293

Chain	Residue
A	HOH64
A	ASP176
A	ASN208
A	GLY210
A	ASP212
A	HOH312

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 294

Chain	Residue
A	HIS239
A	HIS243
A	HIS249
B	CYS301

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 295

Chain	Residue
A	HIS186
A	ASP188
A	HIS201
A	HIS214

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 296

Chain	Residue
A	ASP193
A	GLY194
A	GLY196
A	PHE198
A	ASP216
A	GLU219

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAVHELGHAL

Chain	Residue	Details
D	VAL236-LEU245

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site_id	PS00288
Number of Residues	13
Details	TIMP Tissue inhibitors of metalloproteinases signature. CtCaPvHPQtaFC

Chain	Residue	Details
B	CYS301-CYS313

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22427646

Chain	Residue	Details
B	CYS301
C	CYS301

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in metalloproteinase-binding => ECO:0000269|PubMed:22427646, ECO:0007744|PDB:3V96

Chain	Residue	Details
B	LEU334
D	ASP212
D	HIS214
D	ASP216
D	GLU219
D	HIS239
D	HIS243
D	HIS249
A	HIS186
A	ASP188
A	ASP193
C	LEU334
A	GLY194
A	GLY196
A	PHE198
A	HIS201
A	ASN208
A	GLY210
A	ASP212
A	HIS214
A	ASP216
A	GLU219
D	ASP193
A	HIS239
A	HIS243
A	HIS249
D	GLY194
D	GLY196
D	PHE198
D	HIS201
D	ASN208
D	GLY210

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19139490

Chain	Residue	Details
B	ASN330
C	ASN330

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002

Chain	Residue	Details
B	ASN378
C	ASN378

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