3LZV

Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir.

Summary for 3LZV

• Entry DOI: 10.2210/pdb3lzv/pdb
• Related: 3LZS 3LZU
• Descriptor: HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: hiv-1 protease, resistance, hydrolase
• Biological source: HIV-1 M:B_ARV2/SF2
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22803.18

Authors

Schiffer, C.A.,Kolli, M. (deposition date: 2010-03-01, release date: 2010-08-11, Last modification date: 2023-09-06)

• Primary citation: Bandaranayake, R.M.,Kolli, M.,King, N.M.,Nalivaika, E.A.,Heroux, A.,Kakizawa, J.,Sugiura, W.,Schiffer, C.A.; The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways.; J.Virol., 84:9995-10003, 2010; PubMed: 20660190; DOI: 10.1128/JVI.00505-10

Experimental method

X-RAY DIFFRACTION (2.15 Å)