3LZS

Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir

Summary for 3LZS

Entry DOI	10.2210/pdb3lzs/pdb
Related	3LZU 3LZV
Descriptor	HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, ... (4 entities in total)
Functional Keywords	hiv-1 protease, non-b clades, crf01_ae, inhibitor resistance, aids, aspartyl protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22258.39
Authors	Schiffer, C.A.,Bandaranayake, R.M. (deposition date: 2010-03-01, release date: 2010-08-11, Last modification date: 2023-09-06)
Primary citation	Bandaranayake, R.M.,Kolli, M.,King, N.M.,Nalivaika, E.A.,Heroux, A.,Kakizawa, J.,Sugiura, W.,Schiffer, C.A. The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways. J.Virol., 84:9995-10003, 2010 Cited by PubMed: 20660190 DOI: 10.1128/JVI.00505-10 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation