3LZS
Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10766.8 | 2 | UniProt (Q9QB59) Pfam (PF00077) UniProt (by SIFTS) (P24740) | Human immunodeficiency virus 1 | |
| 2 | C (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | D, E, F (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q9QB59)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21533.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 724.8 | |
| All* | Total formula weight | 22258.4 |
