3LPF
Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea
Summary for 3LPF
Entry DOI | 10.2210/pdb3lpf/pdb |
Related | 3K46 3K4A 3K4D 3LPG |
Descriptor | Beta-glucuronidase, 1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea (3 entities in total) |
Functional Keywords | alpha/beta barrel, sugar-binding domain, beta-sandwich domain, glycosyl hydrolase, beta-glucuronidase inhibitor, glycosidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 139536.24 |
Authors | Wallace, B.D.,Redinbo, M.R. (deposition date: 2010-02-05, release date: 2010-11-17, Last modification date: 2023-11-22) |
Primary citation | Wallace, B.D.,Wang, H.,Lane, K.T.,Scott, J.E.,Orans, J.,Koo, J.S.,Venkatesh, M.,Jobin, C.,Yeh, L.A.,Mani, S.,Redinbo, M.R. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science, 330:831-835, 2010 Cited by PubMed: 21051639DOI: 10.1126/science.1191175 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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