3LMS

Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.

Summary for 3LMS

Entry DOI	10.2210/pdb3lms/pdb
Related	3d4u 3d66 3d6v
Descriptor	Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ... (9 entities in total)
Functional Keywords	fibrinolysis, cogaulation, funnelin, alpha-beta-hydrolase, metallopeptidase, alternative splicing, carboxypeptidase, disulfide bond, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen, blood coagulation, metalloenzyme inhibitor, metalloprotease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rhipicephalus bursa More
Cellular location	Secreted: Q96IY4 Q5EPH2
Total number of polymer chains	2
Total formula weight	44375.88
Authors	Sanglas, L.,Arolas, J.L.,Valnickova, Z.,Aviles, F.X.,Enghild, J.J.,Gomis-Ruth, F.X. (deposition date: 2010-02-01, release date: 2010-02-16, Last modification date: 2023-11-01)
Primary citation	Sanglas, L.,Arolas, J.L.,Valnickova, Z.,Aviles, F.X.,Enghild, J.J.,Gomis-Ruth, F.X. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor J.Thromb.Haemost., 8:1056-1065, 2010 Cited by PubMed: 20088943 DOI: 10.1111/j.1538-7836.2010.03740.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation