3LMS
Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0042730 | biological_process | fibrinolysis |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005575 | cellular_component | cellular_component |
| B | 0005576 | cellular_component | extracellular region |
| B | 0007596 | biological_process | blood coagulation |
| B | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| B | 0010466 | biological_process | negative regulation of peptidase activity |
| B | 0010951 | biological_process | negative regulation of endopeptidase activity |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0044002 | biological_process | acquisition of nutrients from host |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 309 |
| Chain | Residue |
| A | HIS69 |
| A | GLU72 |
| A | HIS196 |
| B | LEU74 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GLY A 501 |
| Chain | Residue |
| B | LEU74 |
| A | HIS69 |
| A | ARG127 |
| A | ASN144 |
| A | ARG145 |
| A | TYR248 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 502 |
| Chain | Residue |
| B | GLY39 |
| B | CYS40 |
| B | LYS41 |
| B | SER63 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | PHE132 |
| A | ILE139 |
| A | CYS166 |
| A | GLY167 |
| A | HOH526 |
| A | HOH528 |
| A | HOH530 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | SER5 |
| A | GLY84 |
| A | HIS85 |
| A | GLN88 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 505 |
| Chain | Residue |
| A | TRP73 |
| A | ARG124 |
| A | PHE279 |
| A | LEU280 |
| A | LEU281 |
| B | GLY7 |
| B | PHE8 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 506 |
| Chain | Residue |
| A | TYR118 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 507 |
| Chain | Residue |
| A | HIS137 |
| A | SER160 |
| A | CA509 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 508 |
| Chain | Residue |
| A | CA509 |
| B | SER28 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 509 |
| Chain | Residue |
| A | LYS122 |
| A | SER159 |
| A | CYS161 |
| A | CL507 |
| B | CL508 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K A 510 |
| Chain | Residue |
| A | GLN95 |
| A | ARG306 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K A 511 |
| Chain | Residue |
| A | ASN16 |
| B | GLY67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 |
| Chain | Residue | Details |
| A | GLU270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:18559974, ECO:0000269|PubMed:20088943 |
| Chain | Residue | Details |
| A | HIS69 | |
| A | GLU72 | |
| A | HIS196 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00730 |
| Chain | Residue | Details |
| A | ARG127 | |
| A | ASN144 | |
| A | SER197 | |
| A | TYR248 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by thrombin |
| Chain | Residue | Details |
| A | ARG210 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:16445295 |
| Chain | Residue | Details |
| A | ASN129 |
