3LJZ
Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound
Summary for 3LJZ
Entry DOI | 10.2210/pdb3ljz/pdb |
Related | 3HY9 3HYG 3LJT |
Descriptor | Collagenase 3, CALCIUM ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | mmp-13 inhibitor; zinc chelating agent; s1' pocket, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 4 |
Total formula weight | 78234.15 |
Authors | Shieh, H.-S.,Kiefer, J.R. (deposition date: 2010-01-26, release date: 2011-02-02, Last modification date: 2024-02-21) |
Primary citation | Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D. Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci., 20:735-744, 2011 Cited by PubMed: 21370305DOI: 10.1002/pro.606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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