3LJZ

Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound

3LJZ の概要

• エントリーDOI: 10.2210/pdb3ljz/pdb
• 関連するPDBエントリー: 3HY9 3HYG 3LJT
• 分子名称: Collagenase 3, CALCIUM ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: mmp-13 inhibitor; zinc chelating agent; s1' pocket, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P45452
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78234.15

構造登録者

Shieh, H.-S.,Kiefer, J.R. (登録日: 2010-01-26, 公開日: 2011-02-02, 最終更新日: 2024-02-21)

• 主引用文献: Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D.; Structure analysis reveals the flexibility of the ADAMTS-5 active site.; Protein Sci., 20:735-744, 2011; PubMed: 21370305; DOI: 10.1002/pro.606

実験手法

X-RAY DIFFRACTION (2 Å)