3LJT

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

3LJT の概要

• エントリーDOI: 10.2210/pdb3ljt/pdb
• 関連するPDBエントリー: 3HY9 3HYG 3LJZ
• 分子名称: A disintegrin and metalloproteinase with thrombospondin motifs 5, (2R)-2-[4-(1,3-benzodioxol-5-yl)benzyl]-N~4~-hydroxy-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: alpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : Q9UNA0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24827.43

構造登録者

Shieh, H.-S.,Williams, J.M.,Caspers, N. (登録日: 2010-01-26, 公開日: 2010-03-31, 最終更新日: 2023-09-06)

• 主引用文献: Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D.; Structure analysis reveals the flexibility of the ADAMTS-5 active site.; Protein Sci., 20:735-744, 2011; PubMed: 21370305; DOI: 10.1002/pro.606

実験手法

X-RAY DIFFRACTION (1.6 Å)