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3LJ7

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate inhibitor URB597

Summary for 3LJ7
Entry DOI10.2210/pdb3lj7/pdb
Related2vya 2wap 3LJ6
DescriptorFatty-acid amide hydrolase 1, CYCLOHEXANE AMINOCARBOXYLIC ACID, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, faah, fatty acid amide hydrolase, carbamate, inhibitor, covalent, endoplasmic reticulum, golgi apparatus, membrane, transmembrane, hydrolase
Biological sourceRattus norvegicus (rat)
Cellular locationEndoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains2
Total formula weight126580.60
Authors
Mileni, M.,Stevens, R.C.,Kamtekar, S. (deposition date: 2010-01-25, release date: 2010-06-09, Last modification date: 2023-09-06)
Primary citationMileni, M.,Kamtekar, S.,Wood, D.C.,Benson, T.E.,Cravatt, B.F.,Stevens, R.C.
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation
J.Mol.Biol., 400:743-754, 2010
Cited by
PubMed: 20493882
DOI: 10.1016/j.jmb.2010.05.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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