3LJ6
3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 at 2.42A RESOLUTION
Summary for 3LJ6
Entry DOI | 10.2210/pdb3lj6/pdb |
Related | 2vya 2wap 3LJ7 |
Descriptor | Fatty-acid amide hydrolase 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, faah, fatty acid amide hydrolase, urea, inhibitor, covalent, endoplasmic reticulum, golgi apparatus, membrane, transmembrane, hydrolase |
Biological source | Rattus norvegicus (rat) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 127019.50 |
Authors | Mileni, M.,Stevens, R.C.,Kamtekar, S. (deposition date: 2010-01-25, release date: 2010-06-09, Last modification date: 2023-09-06) |
Primary citation | Mileni, M.,Kamtekar, S.,Wood, D.C.,Benson, T.E.,Cravatt, B.F.,Stevens, R.C. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation J.Mol.Biol., 400:743-754, 2010 Cited by PubMed: 20493882DOI: 10.1016/j.jmb.2010.05.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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