3LI0
Crystal structure of the mutant R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Summary for 3LI0
Entry DOI | 10.2210/pdb3li0/pdb |
Related | 3LHT 3LHU 3LHV 3LHW 3LHY 3LHZ 3LI1 |
Descriptor | Orotidine 5'-phosphate decarboxylase, 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID (3 entities in total) |
Functional Keywords | mutant r203a, 6-hydroxyuridine-5'-phosphate, decarboxylase, pyrimidine biosynthesis, lyase |
Biological source | Methanothermobacter thermautotrophicus |
Total number of polymer chains | 2 |
Total formula weight | 50277.53 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-01-23, release date: 2010-06-16, Last modification date: 2023-09-06) |
Primary citation | Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629DOI: 10.1021/bi301188k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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