3LHW

Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Summary for 3LHW

Entry DOI	10.2210/pdb3lhw/pdb
Related	3LHT 3LHU 3LHV 3LHY 3LHZ 3LI0 3LI1
Descriptor	Orotidine 5'-phosphate decarboxylase, 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID (3 entities in total)
Functional Keywords	mutant v182a, 6-hydroxyuridine-5'-phosphate, decarboxylase, pyrimidine biosynthesis, lyase
Biological source	Methanothermobacter thermautotrophicus
Total number of polymer chains	2
Total formula weight	50393.65
Authors	Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-01-23, release date: 2010-06-16, Last modification date: 2023-09-06)
Primary citation	Wood, B.M.,Amyes, T.L.,Fedorov, A.A.,Fedorov, E.V.,Shabila, A.,Almo, S.C.,Richard, J.P.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49:3514-3516, 2010 Cited by PubMed: 20369850 DOI: 10.1021/bi100443a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation