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3LHU

Crystal structure of the mutant I199F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Summary for 3LHU
Entry DOI10.2210/pdb3lhu/pdb
Related3LHT 3LHV 3LHW 3LHY 3LHZ 3LI0 3LI1
DescriptorOrotidine 5'-phosphate decarboxylase, 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID (3 entities in total)
Functional Keywordsmutant i199f, 6-hydroxyuridine-5'-phosphate, decarboxylase, pyrimidine biosynthesis, lyase
Biological sourceMethanothermobacter thermautotrophicus
Total number of polymer chains2
Total formula weight50517.79
Authors
Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-01-23, release date: 2010-06-16, Last modification date: 2023-09-06)
Primary citationWood, B.M.,Amyes, T.L.,Fedorov, A.A.,Fedorov, E.V.,Shabila, A.,Almo, S.C.,Richard, J.P.,Gerlt, J.A.
Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.
Biochemistry, 49:3514-3516, 2010
Cited by
PubMed: 20369850
DOI: 10.1021/bi100443a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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