3LDW

Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound

Summary for 3LDW

Entry DOI	10.2210/pdb3ldw/pdb
Descriptor	Farnesyl pyrophosphate synthase, ZOLEDRONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (7 entities in total)
Functional Keywords	malaria, farnesyl pyrophosphate synthase diphosphate, lyase, structural genomics, isoprene biosynthesis, transferase, structural genomics consortium, sgc
Biological source	Plasmodium vivax
Total number of polymer chains	4
Total formula weight	187627.81
Authors	Wernimont, A.K.,Lew, J.,Zhao, Y.,Kozieradzki, I.,Cossar, D.,Schapira, M.,Bochkarev, A.,Arrowsmith, C.H.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Hui, R.,Artz, J.D.,Structural Genomics Consortium (SGC) (deposition date: 2010-01-13, release date: 2010-11-17, Last modification date: 2024-02-21)
Primary citation	Artz, J.D.,Wernimont, A.K.,Dunford, J.E.,Schapira, M.,Dong, A.,Zhao, Y.,Lew, J.,Russell, R.G.,Ebetino, F.H.,Oppermann, U.,Hui, R. Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286:3315-3322, 2011 Cited by PubMed: 21084289 DOI: 10.1074/jbc.M109.027235 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation