3LDW

Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Farnesyl pyrophosphate synthase	polymer	396	46215.8	4	UniProt (A5K4U6) Pfam (PF00348)	Plasmodium vivax
2	E, L, S, X (A, B, C, D)	ZOLEDRONIC ACID	non-polymer		272.1	4	Chemie (ZOL)
3	F, M, T, Y (A, B, C, D)	3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE	non-polymer		246.1	4	Chemie (IPE)
4	AA, BA, G, H, I... (D, A, B, C)	MAGNESIUM ION	non-polymer		24.3	12	Chemie (MG)
5	J, R (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	CA, K, Q (D, A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7	DA, EA, FA, GA (A, B, C, D)	water	water		18.0	562	Chemie (HOH)

Sequence modifications

A, B, C, D: 22 - 396 (UniProt: A5K4U6)

PDB	External Database	Details
Met 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Arg 14	-	expression tag
Glu 15	-	expression tag
Asn 16	-	expression tag
Leu 17	-	expression tag
Tyr 18	-	expression tag
Phe 19	-	expression tag
Gln 20	-	expression tag
Gly 21	-	expression tag
Met 134	Thr 113	SEE REMARK 999
Asp 227	Asn 206	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	184863.0
Non-Polymers*	Number of molecules	25
	Total formula weight	2764.8
All*	Total formula weight	187627.8

*Water molecules are not included.