3LAW
Structure of GTP-bound L129F mutant Rab7
Summary for 3LAW
Entry DOI | 10.2210/pdb3law/pdb |
Descriptor | Ras-related protein Rab-7a, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total) |
Functional Keywords | protein - nucleotide complex, protein mutant, charcot-marie-tooth disease, cytoplasmic vesicle, disease mutation, endosome, gtp-binding, lipoprotein, lysosome, methylation, neuropathy, nucleotide-binding, phosphoprotein, prenylation, protein transport, proton transport |
Biological source | Homo sapiens (human) |
Cellular location | Late endosome: P51149 |
Total number of polymer chains | 5 |
Total formula weight | 120486.17 |
Authors | McCray, B.A.,Skordalakes, E.,Taylor, J.P. (deposition date: 2010-01-07, release date: 2010-01-26, Last modification date: 2024-02-21) |
Primary citation | McCray, B.A.,Skordalakes, E.,Taylor, J.P. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum.Mol.Genet., 19:1033-1047, 2010 Cited by PubMed: 20028791DOI: 10.1093/hmg/ddp567 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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