3L33
Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)
Summary for 3L33
Entry DOI | 10.2210/pdb3l33/pdb |
Related | 1ZJD 2R9P |
Descriptor | Trypsin-3, Amyloid beta A4 protein, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | human mesotrypsin, alzheimer's amyloid precursor protein inhibitor, appi, serine protease inhibitor, hydrolase-cell adhesion complex, hydrolase/cell adhesion |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P35030 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 8 |
Total formula weight | 121342.62 |
Authors | Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2009-12-16, release date: 2010-09-22, Last modification date: 2011-07-13) |
Primary citation | Salameh, M.A.,Soares, A.S.,Navaneetham, D.,Sinha, D.,Walsh, P.N.,Radisky, E.S. Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin. J.Biol.Chem., 285:36884-36896, 2010 Cited by PubMed: 20861008DOI: 10.1074/jbc.M110.171348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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