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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3L33

Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
G	0004867	molecular_function	serine-type endopeptidase inhibitor activity
H	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 1

Chain	Residue
A	LYS230
A	HOH350

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 2

Chain	Residue
A	GLU70
A	ILE73
A	HOH315

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 3

Chain	Residue
A	ASP236
A	TRP237
A	FMT5
A	ASN233
A	TYR234
A	VAL235

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 4

Chain	Residue
A	LYS222

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 5

Chain	Residue
A	FMT3

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 6

Chain	Residue
A	SER119
A	THR120
A	HOH308
A	HOH351
C	ILE121
C	SER122
C	GLY203

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 7

Chain	Residue
A	GLU24
A	LEU27
A	GLU70
A	HIS71
A	HOH306

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 8

Chain	Residue
A	ASP97
A	HOH355

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 9

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU77
A	GLU80

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 1

Chain	Residue
B	PRO129
B	LYS230

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT B 3

Chain	Residue
B	FMT2
B	LYS175
B	HOH307
B	HOH310

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 2

Chain	Residue
B	FMT3
B	ASP97

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT B 5

Chain	Residue
B	HIS91
B	TRP237
C	GLY174

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT B 4

Chain	Residue
B	ASN223

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 6

Chain	Residue
B	GLU70
B	ASN72
B	VAL75
B	GLU77
B	GLU80
B	HOH349

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT C 1

Chain	Residue
C	LYS230

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT C 2

Chain	Residue
B	ASP236
C	LYS169
C	ILE176

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 3

Chain	Residue
C	GLU70
C	ASN72
C	VAL75
C	GLU80
C	HOH303

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT D 1

Chain	Residue
D	LEU163
D	HOH300

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 2

Chain	Residue
D	GLU70
D	ASN72
D	VAL75
D	GLU77
D	GLU80

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT E 56

Chain	Residue
E	ASP24
E	THR26
E	HOH313

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT F 56

Chain	Residue
B	HIS91

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT G 56

Chain	Residue
G	ASP24
G	THR26

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FfyGGCggnrnnFdteeyC

Chain	Residue	Details
E	PHE33-CYS51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Reactive bond

Chain	Residue	Details
E	ARG15
D	HIS57
D	ASP102
D	ALA195
F	ARG15
G	ARG15
H	ARG15
B	ASP102
B	ALA195
C	HIS57
C	ASP102
C	ALA195

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Sulfotyrosine => ECO:0000255

Chain	Residue	Details
E	TYR50
D	GLU70
D	ASN72
D	VAL75
F	TYR50
G	TYR50
H	TYR50
B	ASN72
B	VAL75
C	GLU70
C	ASN72
C	VAL75

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11827488, ECO:0000269\|PubMed:25301953, ECO:0000269\|PubMed:27810896, ECO:0007744\|PDB:1H4W, ECO:0007744\|PDB:3L33, ECO:0007744\|PDB:3L3T, ECO:0007744\|PDB:3P92, ECO:0007744\|PDB:3P95, ECO:0007744\|PDB:4U30, ECO:0007744\|PDB:4U32, ECO:0007744\|PDB:5JBT

Chain	Residue	Details
A	GLU77
B	GLU77
C	GLU77
D	GLU77

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11827488, ECO:0000269\|PubMed:25301953, ECO:0000269\|PubMed:27810896, ECO:0007744\|PDB:1H4W, ECO:0007744\|PDB:3L33, ECO:0007744\|PDB:3L3T, ECO:0007744\|PDB:3P92, ECO:0007744\|PDB:3P95, ECO:0007744\|PDB:4U32, ECO:0007744\|PDB:5JBT, ECO:0007744\|PDB:5TP0

Chain	Residue	Details
A	GLU80
B	GLU80
C	GLU80
D	GLU80

site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Required for specificity => ECO:0000250

Chain	Residue	Details
A	ASP189
B	ASP189
C	ASP189
D	ASP189

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Sulfotyrosine => ECO:0000250

Chain	Residue	Details
A	TYR151
B	TYR151
C	TYR151
D	TYR151

219515

PDB entries from 2024-05-08

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