3L33
Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Trypsin-3 | polymer | 224 | 24257.5 | 4 | UniProt (P35030) Pfam (PF00089) | Homo sapiens (human) | Trypsin III, Brain trypsinogen, Mesotrypsinogen, Trypsin IV, Serine protease 3, Serine protease 4 |
| 2 | E, F, G, H (E, F, G, H) | Amyloid beta A4 protein | polymer | 52 | 5819.5 | 4 | UniProt (P05067) Pfam (PF00014) | Homo sapiens (human) | Alzheimer disease amyloid protein, ABPP, APPI, APP |
| 3 | AA, CA, DA, EA, I... (D, E, F, G, A...) | FORMIC ACID | non-polymer | 46.0 | 19 | Chemie (FMT) | |||
| 4 | BA, Q, W, Z (D, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 16 - 246 (UniProt: P35030)
| PDB | External Database | Details |
|---|---|---|
| Ala 127 | Thr 188 | variant |
| Ala 195 | Ser 257 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 120307.8 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 1034.8 | |
| All* | Total formula weight | 121342.6 |
