3L2V

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and MK0518 (Raltegravir)

3L2V の概要

• エントリーDOI: 10.2210/pdb3l2v/pdb
• 関連するPDBエントリー: 3DLR 3L2Q 3L2R 3L2S 3L2T 3L2U 3L2W
• 分子名称: Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ... (8 entities in total)
• 機能のキーワード: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, zinc, dna-binding, zinc binding, hhcc motif, viral protein, recombination, recombination-dna complex, recombination/dna
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu))
• 細胞内の位置: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101002.66

構造登録者

Hare, S.,Gupta, S.S.,Cherepanov, P. (登録日: 2009-12-15, 公開日: 2010-02-09, 最終更新日: 2023-11-01)

• 主引用文献: Hare, S.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P.; Retroviral intasome assembly and inhibition of DNA strand transfer; Nature, 464:232-236, 2010; PubMed: 20118915; DOI: 10.1038/nature08784

実験手法

X-RAY DIFFRACTION (3.2 Å)