3L26
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Summary for 3L26
Entry DOI | 10.2210/pdb3l26/pdb |
Related | 3FKE 3L25 3L27 3L28 3L29 3L2A |
Descriptor | Polymerase cofactor VP35, RNA (5'-R(*CP*GP*CP*AP*UP*GP*CP*G)-3'), MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | rna binding domain, interferon antiviral evasion, rna replication, rna binding protein, transcription, host cytoplasm, interferon antiviral system evasion, rna-binding, virion, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Zaire ebolavirus (ZEBOV) |
Cellular location | Virion: Q05127 |
Total number of polymer chains | 3 |
Total formula weight | 31261.41 |
Authors | Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. (deposition date: 2009-12-14, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat.Struct.Mol.Biol., 17:165-172, 2010 Cited by PubMed: 20081868DOI: 10.1038/nsmb.1765 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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