Structural basis of GW182 recognition by poly(A)-binding protein

Summary for 3KTP

DescriptorPolyadenylate-binding protein 1, Trinucleotide repeat-containing gene 6C protein (3 entities in total)
Functional Keywordsprotein-protein complex, methylation, mrna processing, mrna splicing, nucleus, phosphoprotein, rna-binding, spliceosome, rna-mediated gene silencing, translation regulation, protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P11940
Total number of polymer chains2
Total molecular weight11884.67
Kozlov, G.,Gehring, K. (deposition date: 2009-11-25, release date: 2010-02-23, Last modification date: 2011-07-13)
Primary citation
Kozlov, G.,Safaee, N.,Rosenauer, A.,Gehring, K.
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.
J.Biol.Chem., 285:13599-13606, 2010
PubMed: 20181956 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.089540
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.229200 5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02