3KS8

Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA

3KS8 の概要

• エントリーDOI: 10.2210/pdb3ks8/pdb
• 関連するPDBエントリー: 3FKE 3KS4
• 分子名称: 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35, ... (4 entities in total)
• 機能のキーワード: ebolavirus, rna-binding protein, protein-rna complex, interferon, reston, host cytoplasm, interferon antiviral system evasion, rna replication, rna-binding, transcription, virion, viral protein-rna complex, viral protein/rna
• 由来する生物種: Reston ebolavirus (REBOV)
• 細胞内の位置: Virion: Q8JPY0
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 93789.65

構造登録者

Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O. (登録日: 2009-11-20, 公開日: 2010-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O.; Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.; Proc.Natl.Acad.Sci.USA, 107:314-319, 2009; PubMed: 20018665; DOI: 10.1073/pnas.0910547107

実験手法

X-RAY DIFFRACTION (2.401 Å)